Title :
Opto-mechanical microbridles for the determination of structural and functional properties of small resistance arteries
Author :
Rodriguez-Rodriguez, Rosalia ; Plaza, J.A. ; Matchkov, Vladimir ; Simonsen, Ulf ; Herrera, Maria Dolores ; Buttgenbach, Stephanus ; Llobera, Andreu ; Munoz-Berbel, Xavier
Author_Institution :
Univ. of Seville, Sevilla, Spain
Abstract :
This work presents a polydimethylsiloxane (PDMS) system (named microbridle) monolithically integrating optical (microlenses, air mirrors etc.) and mechanical elements (cantilever) for the real time monitoring of dilatation and contraction events in small resistance arteries. Structural (response to intraluminal pressure changes) and functional properties (response to vasoactive substances) of mesenteric arteries were determined with the microbridle structure and compared to those obtained with conventional myograph systems. Both systems provide comparable data although microbridles were found advantageous in terms of precision, resolution (below the μm) and reliability for the poor contrast between sample and surrounding medium that impede reliable myography recordings.
Keywords :
biomechanics; blood vessels; cantilevers; cardiovascular system; electromyography; integrated optoelectronics; microlenses; mirrors; polymers; PDMS system; air mirrors; cantilever; contraction event monitoring; dilatation event monitoring; intraluminal pressure changes; mechanical elements; mesenteric artery functional properties; mesenteric artery structural properties; microlenses; monolithic integrated optics; myography recording systems; optomechanical microbridles; polydimethylsiloxane system; vasoactive substances; Arteries; Lenses; Microoptics; Mirrors; Optical fibers; Resistance;
Conference_Titel :
Micro Electro Mechanical Systems (MEMS), 2014 IEEE 27th International Conference on
Conference_Location :
San Francisco, CA
DOI :
10.1109/MEMSYS.2014.6765779
