Title :
A novel extracorporeal shock wave system for enhancing microcirculation and angiogenesis after full thickness burn in an animal study
Author :
Khaled, Walaa ; Goertz, Ole ; Lauer, H. ; Lehnhardt, Marcus ; Hauser, John
Author_Institution :
Dept. of R&D, Dornier MedTech Syst. GmbH, Wessling, Germany
Abstract :
The extended wounds of burn patients remain a challenge due to wound infection and following septicemia. The aim of this study was to analyze microcirculation, angiogenesis and leukocyte endothelium interaction after burn injury with and without extracorporeal shock wave application (ESWA). A novel shockwave system was developed based on a commercially available device for orthopedics (Dornier Aries®) that was equipped with a newly developed applicator. This system is based on the electromagnetic shock wave emitter (EMSE) technology and was introduced to accomplish a localized treatment for wound healing. The system includes a novel field of focus for new applications, with high precision and ease of use. In the animal study, full-thickness burns were inflicted on to the ears of hairless mice (n=51). Intravital fluorescent microscopy was used to assess microcirculatory parameters, angiogenesis and leukocyte behavior. ESWA was performed on day 1, 3 and 7. Values were obtained immediately after burn, as well as at days 1, 3, 7, and 12 post burn. All shockwave treated groups showed an accelerated angiogenesis with a less non-perfused area and an improved blood flow after burn injury compared to the placebo control group. After three treatments, the shock waves increased the number of rolling leukocytes significantly compared to the nontreated animals. Shock waves seem to have a positive effect on several parameters of wound healing after burn injury. However, further investigations are necessary to detect positive influence of shock waves on microcirculation after burn injuries.
Keywords :
blood vessels; cellular biophysics; ear; fluorescence; haemodynamics; injuries; orthopaedics; shock wave effects; ultrasonic therapy; wounds; Dornier Aries; angiogenesis analysis; angiogenesis enhancement; animal study; blood flow; burn injury treatment; ear; electromagnetic shock wave emitter technology; extracorporeal shock wave system; full-thickness burn; hairless mice; intravital fluorescent microscopy; leukocyte endothelium interaction analysis; microcirculation analysis; microcirculation enhancement; microcirculatory parameter assessment; orthopedics; septicemia; time 1 day; time 12 day; time 3 day; time 7 day; wound healing; wound infection; Ear; Medical treatment; Mice; Microscopy; Shock waves; Wounds; Angiogenesis; Deep burn injury; Dornier Aries; Extracorporeal shock wave therapy; Microcirculation;
Conference_Titel :
Ultrasonics Symposium (IUS), 2012 IEEE International
Conference_Location :
Dresden
Print_ISBN :
978-1-4673-4561-3
DOI :
10.1109/ULTSYM.2012.0112