Title :
A silicon pancreatic beta cell based on the phantom bursting model
Author :
Deep, Harkanwal ; Georgiou, Pantelis ; Toumazou, Christofer
Author_Institution :
Dept. of Electr. & Electron. Eng., Imperial Coll. London, London, UK
Abstract :
In this paper a bio-inspired silicon beta cell implementation based on the phantom bursting model is presented. The advantage of this model is that it can show wider range of bursting behaviour compared to previously implemented models which only exhibit a single type of bursting. This allows for design of a more physiological artificial pancreas. Designed a typical 0.35 μm process, this silicon beta cell is capable of exhibiting fast, medium and slow bursting by changing a value of single parameter allowing burst periods of up to 45 seconds. Using multiple burst periods allows tuning of the cell according to a diabetic subjects insulin requirements.
Keywords :
CMOS integrated circuits; artificial organs; biomedical electronics; cellular biophysics; medical control systems; patient care; CMOS process; bioinspired silicon beta cell implementation; bursting behaviour; diabetis; insulin requirements; phantom bursting model; physiological artificial pancreas; silicon pancreatic beta cell; Diabetes; Equations; Insulin; Integrated circuit modeling; Mathematical model; Phantoms; Silicon;
Conference_Titel :
Biomedical Circuits and Systems Conference (BioCAS), 2011 IEEE
Conference_Location :
San Diego, CA
Print_ISBN :
978-1-4577-1469-6
DOI :
10.1109/BioCAS.2011.6107780
