Title :
Parametric imaging in dynamic susceptibility contrast MRI-phantom and in vivo studies
Author :
Ruminski, J. ; Bobek-Billewicz, B.
Author_Institution :
Dept. of Biomed. Eng., Gdansk Univ. of Technol., Poland
Abstract :
Possibility of quantitative perfusion imaging with DSC MRI is still under discussion. In this work, the quantitative related parameters are analyzed and DSC-MRI limitations are discussed. It includes investigation of measurement procedures/conditions as well as parametric image synthesis methodology. The set of phantoms was constructed and used to inspect the role of Gd-DTPA concentration estimation by EPI measurements, the influence of partial volume effect on concentration estimation, the role of a phantom and its pipes orientation, etc. Additionally, parametric image synthesis methodology was investigated by analysis of influence of a bolus dispersion, bolus arrival time, and other signal parameters on an image quality. As a conclusion testing software package is proposed.
Keywords :
biomedical MRI; biomedical measurement; chemical variables measurement; haemorheology; organic compounds; phantoms; software packages; EPI measurement; Gd-DTPA concentration estimation; bolus dispersion; dynamic susceptibility contrast MRI-phantom; echo planar imaging; image quality; parametric imaging; partial volume effect; quantitative perfusion imaging; testing software package; Image analysis; Image generation; Image quality; Imaging phantoms; In vivo; Magnetic resonance imaging; Signal analysis; Software packages; Software testing; Volume measurement; DSC MRI; parametric imaging; phantom studies;
Conference_Titel :
Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE
Conference_Location :
San Francisco, CA
Print_ISBN :
0-7803-8439-3
DOI :
10.1109/IEMBS.2004.1403357
