Title :
IC/microfluidic hybrid system for biology: review
Author :
Liu, Yong ; Lee, Hakho ; Westervelt, Robert M. ; Ham, Donhee
Author_Institution :
Harvard Univ., Cambridge, MA, USA
Abstract :
This paper reviews our recent development of an integrated circuit (IC)/microfluidic hybrid system. The hybrid system consists of an IC chip and a microfluidic channel fabricated on top. Biological cells attached to magnetic beads are suspended inside the microfluidic system that maintains biocompatibility. A microcoil array in the IC produces programmable, spatially-patterned magnetic fields to simultaneously manipulate multiple individual bead-bound cells with precise position control. Two prototypes validate the proposed approach.
Keywords :
biological techniques; biological tissues; magnetic circuits; microfluidics; system-on-chip; IC/microfluidic hybrid system; bead-bound cells; biocompatibility; biolab-on-IC; biological cells; biology; cell manipulations; integrated circuit chip; lab-on-a-chip; magnetic beads; microcoil array; microfluidic channel; precise position control; programmable magnetic fields; spatially-patterned magnetic fields; Biological cells; Hybrid integrated circuits; Lab-on-a-chip; Magnetic fields; Magnetic levitation; Microfluidics; Nanobioscience; Physics; Position control; Prototypes;
Conference_Titel :
Bipolar/BiCMOS Circuits and Technology Meeting, 2005. Proceedings of the
Print_ISBN :
0-7803-9309-0
DOI :
10.1109/BIPOL.2005.1555226
