Title :
Model-based 3-D Reconstructions for the Structural Biology of Viruses Exhibiting Incompatible Symmetries
Author :
Prust, Cory J. ; Doerschuk, Peter C. ; Johnson, John E.
Author_Institution :
Sch. of Electr. & Comput. Eng., Purdue Univ., West Lafayette, IN
Abstract :
A model-based approach to 3-D reconstruction from cryo electron microscope images is presented for the case of a virus particle lacking total particle symmetry. In particular, we consider the reconstruction of a tailed bacteriophage where the symmetries of the capsid and tail are incompatible. We describe a model-based statistical approach and a two-stage reconstruction algorithm. Numerical results from synthetic data are presented
Keywords :
biological techniques; biology computing; electron microscopy; image reconstruction; microorganisms; statistical analysis; 3D reconstructions; capsid; cryo electron microscope images; image reconstruction; statistical approach; structural biology; tail; tailed bacteriophage; total particle symmetry; two-stage reconstruction algorithm; viruses; Assembly; Biological system modeling; Computational biology; Electrons; Fourier transforms; Image reconstruction; Particle scattering; Tail; Three dimensional displays; Viruses (medical);
Conference_Titel :
Electro/information Technology, 2006 IEEE International Conference on
Conference_Location :
East Lansing, MI
Print_ISBN :
0-7803-9592-1
Electronic_ISBN :
0-7803-9593-X
DOI :
10.1109/EIT.2006.252192
