The Mitochondrial Calcium Uniporter participates in Ischemia/Reperfusion Injury and in Cardioprotection by Ischemic Preconditioning

Author

Zhang, S.-Z. ; Xia, Q. ; Cao, C.-M. ; Gao, Q. ; Bruce, I.C.

Author_Institution

Department of Physiology, Zhejiang University School of Medicine, Hangzhou, China

Volume

2

fYear

2004

fDate

1-5 Sept. 2004

Firstpage

3625

Lastpage

3627

Abstract

The objective of the present study was to determine whether the mitochondrial calcium uniporter plays a role in cardioprotection by ischemic preconditioning (IPC). Isolated rat hearts were subjected to 30 min regional ischemia by ligation of the left anterior descending artery followed by 120 min reperfusion. We found that both IPC and inhibition of the mitochondrial calcium uniporter during reperfusion improved recovery of left ventricular developed pressure, maximal rise velocity and end-diastolic pressure, and reduced infarct size and lactate dehydrogenase release. These protective effects were attenuated by activating the mitochondrial calcium uniporter. We conclude that the mitochondrial calcium uniporter is involved in the cardioprotection of ischemic preconditioning.

Keywords

Heart; ischemic preconditioning; mitochondrial calcium uniporter; Arteries; Calcium; Cardiology; Heart; Injuries; Ischemic pain; Myocardium; Physiology; Size measurement; Testing;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE

Print_ISBN

0-7803-8439-3

Type

conf

DOI

10.1109/IEMBS.2004.1404019

Filename

1404019