Title :
A model of the respiratory central pattern generator
Author :
Amini, Behrang ; Bidani, Akhil ; Zwischenberger, Joseph B. ; Clark, John W., Jr.
Author_Institution :
Dept. of Neurobiol. & Anatomy, Texas Univ., Houston, TX, USA
Abstract :
We have developed a model of the mammalian respiratory central pattern generator (rCPG) to mimic the salient characteristics of its constituent medullary neurons. This model was designed as a network of Hodgkin-Huxley type medullary neurons under the hypothesis that synaptic and network effects predominate over ionic influences in determining the pattern of firing seen in individual neurons. After obtaining satisfactory mimicry of these patterns we validated the model to a different set of data in order to examine its robustness in the face of transient perturbations.
Keywords :
bioelectric phenomena; neurophysiology; physiological models; pneumodynamics; Hodgkin-Huxley type medullary neurons; mammalian respiratory central pattern generator; medullary neurons; network effects; neuron firing; respiratory central pattern generator; synaptic effects; Anatomy; Biological system modeling; Biology computing; Biomedical engineering; Computational biology; Consortia; Frequency; Lungs; Nerve fibers; Neurons;
Conference_Titel :
Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE
Conference_Location :
San Francisco, CA
Print_ISBN :
0-7803-8439-3
DOI :
10.1109/IEMBS.2004.1404270