Photothermal nanoblade for single cell surgery

Author

Wu, T.-H. ; Teslaa, T. ; Teitell, M.A. ; Chiou, P.-Y.

Author_Institution

Dept. of Mech. & Aerosp. Eng., Univ. of California at Los Angeles, Los Angeles, CA, USA

fYear

2011

fDate

23-27 Jan. 2011

Firstpage

1055

Lastpage

1058

Abstract

We report a photothermal nanoblade that utilizes a metallic nanostructure to harvest short laser pulse energy and convert it into a highly localized and specifically shaped explosive vapor bubble. Rapid bubble expansion and collapse punctures a lightly-contacting cell membrane via high-speed fluidic flows and induced transient shear stress. The membrane cutting pattern is controlled by the metallic nanostructure configuration, laser pulse polarization, and energy. Highly controllable, sub-micron sized circular hole pairs to half moon-like, or cat-door shaped, membrane cuts were realized in glutaraldehyde treated HeLa cells.

Keywords

biomembranes; bubbles; cellular biophysics; nanobiotechnology; photothermal effects; surgery; bubble collapse; bubble expansion; cell membrane; explosive vapor bubble; glutaraldehyde treated HeLa cell; high speed fluidic flow; laser pulse polarization; metallic nanostructure; photothermal nanoblade; short laser pulse energy harvesting; single cell surgery; transient shear stress; Biomembranes; Heating; Laser beam cutting; Laser excitation; Optical polarization; Optical pulses; Ring lasers;

fLanguage

English

Publisher

ieee

Conference_Titel

Micro Electro Mechanical Systems (MEMS), 2011 IEEE 24th International Conference on

Conference_Location

Cancun

ISSN

1084-6999

Print_ISBN

978-1-4244-9632-7

Type

conf

DOI

10.1109/MEMSYS.2011.5734610

Filename

5734610