Title :
A Urine 1H NMR based metabonomic approach to understand the host metabolic response towards Plasmodium vivax infection
Author :
Sengupta, Arjun ; Ghosh, Soumita ; Sonawat, Haripalsingh M. ; Basant, Angika ; Sharma, Shobhona ; Kshirsagar, N.A. ; Gogtay, N.
Author_Institution :
Dept. of Chem. Sci., Tata Inst. of Fundamental Res., Mumbai, India
Abstract :
External stressors like parasites cause alteration in the metabolic pathways of the host. Monitoring the small molecular weight metabolites in the tissue or biofluid offer a convenient approach to understand these alterations. In this paper, we report a urine 1H NMR based metabonomic study to understand the alterations in the human host during the infection of the malarial parasite Plasmodium vivax. Our study reveals distinct metabolic changes during the disease. Some of them could be useful in order to understand the increasing severity of the P. vivax infection.
Keywords :
biochemistry; biomedical NMR; diseases; microorganisms; molecular biophysics; patient diagnosis; patient monitoring; proton magnetic resonance; Plasmodium vivax infection; biofluid; disease; external stressors; host metabolic response; malarial parasite; metabonomic approach; small molecular weight metabolites; tissue; urine 1H NMR; Analytical models; Diseases; Electron tubes; Hospitals; Microscopy; Monitoring; Nuclear magnetic resonance; Malaria; Metabolism; Metabonomics; NMR; Plasmodium vivax;
Conference_Titel :
Systems in Medicine and Biology (ICSMB), 2010 International Conference on
Conference_Location :
Kharagpur
Print_ISBN :
978-1-61284-039-0
DOI :
10.1109/ICSMB.2010.5735366
