On-line self-organizing fuzzy logic controller with patient simulators

The development of online drug administration strategies in operating theatres represent a highly safety-critical situation. The usefulness of different levels of simulation prior to clinical trials has been shown in previous studies in muscle relaxant anaesthesia. In the present approach the control software was implemented on the actual machine to be used in theatre, while another computer acted as a real-time patient simulator. The paper illustrates the usefulness of the controller/simulator approach via results of scale-factor selection, choice of self-organising fuzzy logic control rule-base, and the effect of the drug sensitivity scheduler