Non-invasive measurement of tissue oxygenation using near infrared (NIR) spectroscopy

Author

Cope, M. ; Der Zee, Piet Van ; Arridge, Simon R. ; Essenpreis, M. ; Elwell, C.E. ; Delpy, D.T.

Author_Institution

Dept. of Med. Phys. & Bioeng., Univ. Coll., London, UK

fYear

1991

fDate

33403

Abstract

Non-invasive optical spectroscopy across many centimetres of living tissue is possible at wavelengths between 650 nm and 1100 nm. The short wavelength cut-off wavelength is caused by absorption of light by haemoglobin and the long wavelength cut-off by water absorption. Typical NIR attenuation coefficients are one optical density loss for each centimetre of tissue travelled. Haemoglobin is present in the circulation, and in its oxygenated (HbO₂) and deoxygenated (Hb) forms acts as an indicator of blood oxygenation while cytochrome c oxidase (Cyt) in its oxidised and reduced forms is present in the tissue and acts as an indicator of intracellular oxygenation. Problems of multiple scattering in tissue spectroscopy are examined and a method proposed for determining the differential pathlength. Possibilities of adapting the technique to bedside monitoring are also discussed

Keywords

biological techniques and instruments; biomedical measurement; infrared spectroscopy; patient monitoring; 650 to 1100 nm; bedside monitoring; blood oxygenation; cut-off wavelength; cytochrome c oxidase; differential pathlength; intracellular oxygenation; living tissue; multiple scattering; near infrared spectroscopy; noninvasive measurement; quantitative spectroscopy; tissue oxygenation; tissue scattering coefficient;

fLanguage

English

Publisher

iet

Conference_Titel

Optical Techniques and Biomedical Applications, IEE Colloquium on

Conference_Location

London

Type

conf

Filename

181801