An integrative approach to cerebrovascular disease healthcare: IT for cerebral aneurysms

One of the central themes in addressing vascular disease is connected with the behavior of the arterial wall; its response to stimuli, its remodeling, the growth or stabilization of lesions and the interaction with implants and drugs. For the case of cerebral aneurysms, we are presenting an effort to embed computational simulation models capable of handling such processes within an IT framework that combines imaging, modeling, genetics and clinical medicine in an integrative and comprehensive fashion. The @neurIST project aims at the development of an IT-enabled patient risk assessment and guidelines generation environment, capable of optimized decision support and treatment design. Within this framework, we present mechanobiological models of the vascular wall that account for the interaction of heamodynamics with vascular wall fiber and cell population and behavior.