Detection performance analysis for time-of-flight PET

Author

Cao, Nannan ; Huesman, Ronald H. ; Moses, William W. ; Qi, Jinyi

Author_Institution

Dept. of Biomed. Eng., Univ. of California at Davis, Davis, CA, USA

fYear

2009

fDate

June 28 2009-July 1 2009

Firstpage

402

Lastpage

405

Abstract

In this paper, we investigate the performance of time-of-flight (TOF) PET in improving lesion detectability. We present a theoretical approach to compare lesion detectability of TOF versus non-TOF systems. Computer simulations are performed to validate the theoretical predictions. A TOF PET tomograph is simulated using the SimSET software. Images are reconstructed from list-mode data using a maximum a posteriori (MAP) method. We use a channelized Hotelling observer (CHO) to assess the detection performance. Both the receiver operating characteristic (ROC) and localization ROC (LROC) curves are compared for the TOF and non-TOF PET systems. We also study the SNR gains for TOF PET with different scatter and random fractions. Simulation results match with the theoretical predictions very well. Both results show that the TOF information improves lesion detectability and the improvement is greater with larger fractions of randoms and scatters.

Keywords

image reconstruction; maximum likelihood estimation; medical image processing; positron emission tomography; sensitivity analysis; wounds; SimSET software; channelized Hotelling observer; computer simulations; lesion detection performance analysis; maximum a posteriori method; random fractions; receiver operating characteristic analysis; scatter fractions; time-of-flight PET; Computational modeling; Computed tomography; Computer simulation; Image reconstruction; Lesions; Light scattering; Particle scattering; Performance analysis; Positron emission tomography; Reconstruction algorithms; Channelized Hotelling observer; LROC; ROC; TOF-PET; lesion detection;

fLanguage

English

Publisher

ieee

Conference_Titel

Biomedical Imaging: From Nano to Macro, 2009. ISBI '09. IEEE International Symposium on

Conference_Location

Boston, MA

ISSN

1945-7928

Print_ISBN

978-1-4244-3931-7

Electronic_ISBN

1945-7928

Type

conf

DOI

10.1109/ISBI.2009.5193069

Filename

5193069