Title :
A Physical basis for multi-fiber reconstruction from DW-MRI data
Author :
Kumar, Ritwik ; Barmpoutis, Angelos ; Vemuri, Baba C. ; Carney, Paul R. ; Mareci, Thomas H.
Author_Institution :
Dept. of Comput. & Inf. Sci. & Eng., Univ. of Florida, Gainesville, FL, USA
fDate :
June 28 2009-July 1 2009
Abstract :
Recently various mathematical models have been proposed to model the signal attenuation obtained from Diffusion Weighted Magnetic Resonance Imaging (DW-MRI). Though effective to various extents, almost all of the existing methods involve model parameters which are abstract mathematical quantities without any tangible connection to physical quantities (e.g. the b-value, gradient pulse duration, pulse separation etc.) involved in the DW-MRI acquisition process. To address this disconnect, in this paper, we present a multi-compartmental model which uses a physical model for restricted diffusion in the cylindrical geometry as the constituent basis function for multi-fiber reconstruction. Through extensive experiments on synthetic data we establish the superiority of the proposed method over the state-of-the-art techniques in terms of fiber orientation detection accuracy. We also present detailed results using human and rat brain data and demonstrate that our method leads to meaningful multi-fiber reconstruction even in the case of real data.
Keywords :
biomedical MRI; brain; image reconstruction; medical image processing; DW-MRI acquisition process; DW-MRI data; diffusion weighted magnetic resonance imaging; fiber orientation detection; gradient pulse duration; human brain; mathematical models; multicompartmental model; multifiber reconstruction; pulse separation; rat brain data; signal attenuation; Attenuation; Biological system modeling; Convolution; Diffusion tensor imaging; Geometry; Image reconstruction; Mathematical model; Solid modeling; Tensile stress; US Department of Transportation; DW-MRI; Multi-fiber Reconstruction;
Conference_Titel :
Biomedical Imaging: From Nano to Macro, 2009. ISBI '09. IEEE International Symposium on
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-3931-7
Electronic_ISBN :
1945-7928
DOI :
10.1109/ISBI.2009.5193125