Use of microwave nondestructive testing (NDT) technique to characterize the film for applications in transdermal drug delivery system

Author

Anuar, Nor Khaizan ; Wui, Wong Tin ; Ghodgaonkar, Deepak K. ; Taib, Mohd Nasir

Author_Institution

Fac. of Pharmacy, Univ. Teknologi MARA, Selangor, Malaysia

fYear

2005

fDate

5-7 Sept. 2005

Firstpage

31

Lastpage

33

Abstract

The present study investigated the potential of microwave nondestructive testing (NDT) technique for use in characterization of film for the application in transdermal drug delivery system. Hydroxypropyl methylcellulose and loratadine were selected as model matrix material and drug, respectively. Both blank and drug-loaded films were prepared using the solvent-evaporation method. The films were subjected to dimensional analysis, drug content assay and dielectric property measurement using electronic calliper, UV spectrophotometry and microwave NDT technique based on rectangular dielectric waveguide (RDWG) measurement system, respectively. The results indicated that the microwave NDT technique using RDWG measurement system is potentially useful to be used in characterization of high drug load films.

Keywords

dielectric waveguides; drug delivery systems; nondestructive testing; spectrophotometry; ultraviolet spectra; UV spectrophotometry; dielectric property; drug content assay; drug load films; electronic calliper; hydroxypropyl methylcellulose; loratadine; microwave nondestructive testing; rectangular dielectric waveguide; solvent-evaporation method; transdermal drug delivery system; Dielectric materials; Dielectric measurements; Drug delivery; Microwave measurements; Microwave theory and techniques; Nondestructive testing; Plastic films; Polymer films; Rectangular waveguides; Skin; Microwave nondestructive testing (NDT) technique; UV Spectrophotometry; rectangular dielectric waveguide (RDWG); transdermal drug delivery system.;

fLanguage

English

Publisher

ieee

Conference_Titel

Sensors and the International Conference on new Techniques in Pharmaceutical and Biomedical Research, 2005 Asian Conference on

Print_ISBN

0-7803-9370-8

Type

conf

DOI

10.1109/ASENSE.2005.1564499

Filename

1564499