Real-time monitoring of self-assembled monolayer using biaxial nanohole arrays

This work demonstrates surface plasmon resonance (SPR) sensing based on the polarization dependence of extraordinary optical transmission through a biaxial nanohole array. This structure provides two nearly-degenerate periodicities in a single array that can be individually probed by varying polarization. This real-time monitoring technique is particularly useful to the on-going microfluidic integration of nanohole SPR, where the light source must be transmitted through the microfluidic channel. Moreover, by utilizing an efficient semiconductor laser source and intensity detector make this sensing technique cost-effective.