Nasopharyngeal cancer cell death induced by high-dose gold nanoparticles

Author

Lan, Ming-Ying ; Hsu, Yen-Bin ; Lin, Jin-Ching ; Ho, Ching-Yin ; Lee, Sheng-Wei

Author_Institution

Dept. of Otolaryngology, Taipei Veterans Gen. Hosp., Taipei, Taiwan

fYear

2011

fDate

21-24 June 2011

Firstpage

1

Lastpage

2

Abstract

This study investigated if gold nanoparticles (AuNPs) could be used as a new therapeutic agent for NPC by evaluating their anti-tumor effect in vitro. AuNPs prepared in this study had an average diameter of 20.5 nm and they were observed under light microscopy as dark material aggregated in the cells after treatment. The AuNPs reduced cell viability in a concentration-dependant manner by Trypan Blue assay: 74.7% at 50 μM, 39.0% at 100μM, and 7.1% at 200 μM, respectively. TUNEL stain was positive in AuNP-treated cells. The AuNP possess specific imaging properties and is cytotoxic to NPC cells at high concentrations.

Keywords

cancer; gold; nanoparticles; optical microscopy; patient treatment; tumours; Au; NPC; TUNEL stain; Trypan Blue assay; antitumor effect; concentration-dependant manner; high-dose gold nanoparticles; nasopharyngeal cancer cell death; therapeutic agents; Cancer; Gold; Materials; Microscopy; Nanoparticles; Surface morphology;

fLanguage

English

Publisher

ieee

Conference_Titel

Nanoelectronics Conference (INEC), 2011 IEEE 4th International

Conference_Location

Tao-Yuan

ISSN

2159-3523

Print_ISBN

978-1-4577-0379-9

Electronic_ISBN

2159-3523

Type

conf

DOI

10.1109/INEC.2011.5991750

Filename

5991750