A High-Density Magnetoresistive Biosensor Array with Drift-Compensation Mechanism

Author

Han, Shu-Jen ; Yu, Heng ; Murmann, Boris ; Pourmand, Nader ; Wang, Shan X.

Author_Institution

Stanford Univ., CA

fYear

2007

fDate

11-15 Feb. 2007

Firstpage

168

Lastpage

594

Abstract

A DNA microarray of 1008 magnetoresistive sensors employing multidivided array structures for detecting either tow concentration or large-scale gene information is integrated with a 0.25mum BiCMOS chip. The input-referred noise is below 55nV/radicHz. Ionic solution interferences and drifts during biological reaction are removed by applying an in-plane AC magnetic field with two DC field states. Parallel readout is realized by combining FDM with TDM.

Keywords

BiCMOS integrated circuits; DNA; biology computing; biosensors; compensation; frequency division multiplexing; magnetoresistive devices; microsensors; time division multiplexing; 0.25 micron; BiCMOS chip; DNA microarray; FDM; TDM; drift-compensation mechanism; gene information; in-plane AC magnetic field; magnetoresistive biosensor array; magnetoresistive sensors; multidivided array structures; parallel readout; tow concentration; BiCMOS integrated circuits; Biosensors; DNA; Interference; Large scale integration; Magnetic fields; Magnetic noise; Magnetic sensors; Magnetoresistance; Sensor arrays;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Circuits Conference, 2007. ISSCC 2007. Digest of Technical Papers. IEEE International

Conference_Location

San Francisco, CA

ISSN

0193-6530

Print_ISBN

1-4244-0853-9

Electronic_ISBN

0193-6530

Type

conf

DOI

10.1109/ISSCC.2007.373347

Filename

4242318