The effect of electrical charge on drug delivery through skin

Author

Chen, Jie ; Chiu, Tsung-Kai ; Lo, Wen ; Sung-Jan Lin ; Jee, Shiou-Hwa ; Dong, Chen-Yuan

Author_Institution

Dept. of Phys., Nat. Taiwan Univ., Taipei, Taiwan

fYear

2004

fDate

14-17 Dec. 2004

Firstpage

175

Lastpage

176

Abstract

Drug delivery through skin has benefits such as its conveniences of providing controlled dosage to patients. In this article we investigate the effects of electrical characteristics of molecules on their effectiveness in transdermal drug delivery. Using multiphoton microscopy, we imaged the skin treated with fluorescent model drugs having different charges. We will present both the images obtained at different depths and axial fluorescence intensity profiles. Multiphoton microscopy is a useful technique for mechanistic analysis in transdermal drug delivery.

Keywords

biomedical optical imaging; drugs; electric charge; fluorescence; molecular biophysics; multiphoton spectroscopy; optical microscopy; skin; axial fluorescence intensity profiles; electrical characteristics; electrical charge; fluorescent model drugs; multiphoton microscopy; skin; transdermal drug delivery; Biomedical imaging; Drug delivery; Educational institutions; Electric variables; Fluorescence; Hospitals; Microscopy; Pharmaceuticals; Physics; Skin;

fLanguage

English

Publisher

ieee

Conference_Titel

Biophotonics, 2004. APBP 2004. The Second Asian and Pacific Rim Symposium on

Print_ISBN

0-7803-8676-0

Type

conf

DOI

10.1109/APBP.2004.1412338

Filename

1412338