DocumentCode
2888846
Title
Pinpoint keV/MeV x-ray sources for x-ray drug delivery system
Author
Uesaka, M. ; Mizuno, K. ; Sakumi, A. ; Meiling, J. ; Yusa, N. ; Takahashi, H. ; Nishiyama, N. ; Kataoka, K. ; Nakagawa, K.
Author_Institution
Univ. of Tokyo, Tokai
fYear
2007
fDate
25-29 June 2007
Firstpage
2793
Lastpage
2795
Abstract
X-ray Drug Delivery System (DDS) is the most advanced radiation therapy coming after IMRT (Intensity Modulated Radiation Therapy) and IGRT (Image Guided Radiation Therapy). DDS uses advanced nano-scaled polymers which contain and deliver a drug or contrast agent to cancers without side effects. Several X-ray DDS poses high-Z atoms like Pt and Au to absorb X-rays effectively and used as a contrast agent for inspection. Moreover, they have a radiation enhancement effect by emission of Auger electron and successive characteristic X-rays. The enhancement factor of Pt and Au is more than five. This can be used for therapy. This new modality must be very important for inspection and therapy of deep cancers. We are making use of our Compton scattering monochromatic keV X-ray source and MeV linac as pinpoint keV/MeV X-ray sources for the purpose. Physical analysis and evaluation of the contrast efficiency and radiation enhancement of the X-ray DDS are under way. Furthermore, a new compact X-band linac with a multi-beam klystron for a pinpoint X-ray source is proposed and designed. An updated research status and results are presented.
Keywords
X-ray production; cancer; drug delivery systems; klystrons; radiation therapy; Auger electron emission; Compton scattering monochromatic X-ray source; X-ray drug delivery system; cancer therapy; compact X-band linac; multibeam klystron; nanoscaled polymers; pinpoint X-ray sources; radiation enhancement effect; radiation therapy; Biomedical applications of radiation; Cancer; Drug delivery; Gold; Inspection; Intensity modulation; Linear particle accelerator; Medical treatment; Polymers; X-ray imaging;
fLanguage
English
Publisher
ieee
Conference_Titel
Particle Accelerator Conference, 2007. PAC. IEEE
Conference_Location
Albuquerque, NM
Print_ISBN
978-1-4244-0916-7
Type
conf
DOI
10.1109/PAC.2007.4440578
Filename
4440578
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