DocumentCode :
2909654
Title :
Use of ion exchange resin for dynamic PET phantom
Author :
Yeh, Eric L. ; Huang, Sung-Cheng ; Barrio, Jorge R. ; Hoffman, Edward J.
Author_Institution :
Div. of Nucl. Med. & Biophys., California Univ., Los Angeles, CA, USA
Volume :
3
fYear :
1998
fDate :
1998
Firstpage :
1493
Abstract :
For evaluation of PET scanners´ capability for dynamic studies, physical phantoms that can simulate realistic tissue kinetics are desirable. In this work, the authors have investigated the use of ion exchange resin to imitate tracer´s radiokinetics in tissue as means to construct a realistic dynamic phantom for PET studies. The authors have constructed a unit cell perfusion system to demonstrate the feasibility of such an approach. The system utilizes competitive binding of 13 NH4+ and Na+ for cation exchange resin sites. Due to the high binding affinity of 13NH4 + to cation exchange resin, efficient tracer uptake can be completed, followed by gradual washout of tracer from binding sites by an aqueous solution of NaCl. The clearance rate of tracer can be modified to achieve desired temporal characteristics by changing either the concentration of NaCl eluent or its flow rate. This unit cell perfusion system was also incorporated into a simple cylinder phantom for dynamic PET imaging. Results from the PET phantom images demonstrated the feasibility of using ion-exchange resin to construct dynamic phantoms for PET
Keywords :
biomedical equipment; ion exchange; polymers; positron emission tomography; 13NH4+; NH4; Na; Na+; NaCl; NaCl aqueous solution; cation exchange resin sites; dynamic PET phantom; ion exchange resin; medical diagnostic imaging; nuclear medicine; unit cell perfusion system; Biomedical imaging; Biophysics; Chemicals; Imaging phantoms; Kinetic theory; Medical simulation; Nuclear medicine; Positron emission tomography; Purification; Resins;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Nuclear Science Symposium, 1998. Conference Record. 1998 IEEE
Conference_Location :
Toronto, Ont.
ISSN :
1082-3654
Print_ISBN :
0-7803-5021-9
Type :
conf
DOI :
10.1109/NSSMIC.1998.773826
Filename :
773826
Link To Document :
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