Simulation study of the effect of Mitragyna speciosa on hybrid current in rat hippocampus CA3 pyramidal neuron

Author

Reza, F. ; Begum, T. ; Ilmie, M.U. ; Hanif, M.C.L. ; Zhang, J. ; Abdullah, J.M.

Author_Institution

Dept. of Neurosciences, Univ. Sains Malaysia Health Campus, Kubang, Malaysia

fYear

2011

fDate

5-8 Dec. 2011

Firstpage

301

Lastpage

305

Abstract

We have simulated the hybrid current using Neurons in Action software to observe the hypothetical effect of Mitragyna speciosa in the model rat hippocampus CA3 pyramidal neuron at different Calcium ion conductance and at different temperature. Previous studies using the patch clamp technique showed that Mitragyna speciosa or Ketum could block long lasting Calcium channel (L-type Ca channel) currents in N1E-115 neuroblastoma cells. There is currently no such study of the effects of ketum on pyramidal neurons using the patch clamp technique. Our team is interested to study the ability of Ketum alakaloid to block L-type Ca channel in a rat´s brain. The results of the simulation study gave us valuable information and guidelines for our future study to replicate the Ca channel blocking nature of the alkaloid of the Mitragyna speciosa.

Keywords

neurophysiology; Action software; Ketum alakaloid; L-type Ca channel; Mitragyna speciosa; N1E-115 neuroblastoma cells; calcium channel; calcium ion conductance; hybrid current; patch clamp technique; rat hippocampus CA3 pyramidal neuron; Calcium; Equations; Mathematical model; Mice; Neurons; Software; Temperature dependence; CA3 Pyramida Neuron; Hybrid Current; Mitragyna Speciosa; Simulation;

fLanguage

English

Publisher

ieee

Conference_Titel

Hybrid Intelligent Systems (HIS), 2011 11th International Conference on

Conference_Location

Melacca

Print_ISBN

978-1-4577-2151-9

Type

conf

DOI

10.1109/HIS.2011.6122122

Filename

6122122