Smart hydrogel based microsensing platform for continuous glucose monitoring

Author

Tathireddy, Prashant ; Avula, Mahender ; Lin, Genyao ; Cho, Seung Hei ; Guenther, Margarita ; Schulz, Volker ; Gerlach, Gerald ; Magda, Jules J. ; Solzbacher, Florian

Author_Institution

Dept. of Electr. & Comput. Eng., Univ. of Utah, Salt Lake City, UT, USA

fYear

2010

fDate

Aug. 31 2010-Sept. 4 2010

Firstpage

677

Lastpage

679

Abstract

In this paper, we present preliminary results showing the response of glucose-sensitive hydrogels, confined in micro-pressure sensors, to the changes in environmental glucose concentration. The glucose concentrations were incrementally varied between 20 and 0mM in 0.15M PBS solution at 7.4 pH and bovine serum at 7.4 pH at room temperature and response of the sensor was recorded. The micro sensors demonstrate a response time of 10 minutes in both PBS and serum. Tissue response after 55 days of subcutaneous implantation of a EtO sterilized sensor in mice is presented. The preliminary analysis of the surrounding tissue shows inflammation which is believed not to interfere with the sensor performance.

Keywords

biological tissues; biomedical measurement; chemical analysis; chemical variables measurement; hydrogels; microsensors; pH; bovine serum; continuous glucose monitoring; glucose concentration; glucose-sensitive hydrogels; micropressure sensors; microsensing platform; pH; sterilized sensor; subcutaneous implantation; temperature 293 K to 298 K; tissue response; Chemical sensors; Diabetes; Monitoring; Sensor arrays; Sugar; Animals; Blood Glucose; Equipment Design; Equipment Failure Analysis; Hydrogels; Manometry; Mice; Miniaturization; Monitoring, Physiologic; Transducers;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE

Conference_Location

Buenos Aires

ISSN

1557-170X

Print_ISBN

978-1-4244-4123-5

Type

conf

DOI

10.1109/IEMBS.2010.5626231

Filename

5626231