Title :
Spiral wave induced numerically using electrical stimulation and comparison with experimental results
Author :
Xu, Binbin ; Jacquir, Sabir ; Laurent, Gabriel ; Bilbault, Jean-Marie ; Binczak, Stéphane
Author_Institution :
Lab. LE2I, Univ. de Bourgogne, Dijon, France
fDate :
Aug. 31 2010-Sept. 4 2010
Abstract :
Experiments in vitro on a Microelectrode Array (MEA) platform show that electrical stimulation can provoke the generation of spiral waves in cardiac tissue. Nevertheless, the conditions leading to this artificial fibrillation state remain unclear. In order to have a better understanding of this phenomenon, a numerical simulation study has been conducted. The results obtained with a two-dimensional FitzHugh-Nagumo model proved that it is possible to create spiral waves by adding a stimulation current under certain conditions, which are made explicit.
Keywords :
bioelectric phenomena; biological tissues; biomedical electrodes; cardiology; microelectrodes; physiological models; artificial fibrillation state; cardiac tissue model; electrical stimulation; microelectrode array; numerical simulation; spiral waves; stimulation current; two-dimensional FitzHugh-Nagumo model; Arrays; Cardiac tissue; Electrical stimulation; Electrodes; In vitro; Numerical models; Spirals; Action Potentials; Algorithms; Animals; Animals, Newborn; Arrhythmias, Cardiac; Biomedical Engineering; Cells, Cultured; Computer Simulation; Electric Stimulation; Electrodes; Electrophysiology; Heart; Models, Cardiovascular; Models, Statistical; Myocardium; Rats;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE
Conference_Location :
Buenos Aires
Print_ISBN :
978-1-4244-4123-5
DOI :
10.1109/IEMBS.2010.5626540
