Optimizing the diameter of holes for flexible regeneration microelectrode

In this study, we suggest a new guideline for regeneration microelectrode to be implanted between the severed stumps of peripheral nerves, the microelectrode designed particularly for connecting the signal line of an artificial hand directly to the nerve system. The nerve regeneration microelectrode is an interface device expected to realize a BMI (brain-machine interface). As the microelectrode device consists of a parylene cable and gold electrodes, it has good flexibility and biocompatibility. The advantage of this technique is that the electrode is in position to make continuous measurements throughout the regeneration process. On the tip of the device, holes are patterned with rounded gold electrodes, where a nerve fiber is growing and passing through each hole during regeneration. By using this unique technique, we can avoid damaging a nerve fiber and make to stable measurement in the long term. We optimized the diameter of the holes located on the device. Furthermore, since the electrode is fully integrated into a nerve bunch, we can both stimulate the nerve cells by applying a voltage pulse to the motor nerve and take sensory nerve measurements. With this extent of control, we can also selectively measure the signals from these nerve fibers.