MML toolkit and work flow overview: Creating temporo-spatial heart models from CellML

The Modeling Markup Language (MML) framework is a conceptual paradigm to quickly develop and solve biological models utilizing the CellML specification. In this study, we present the open source toolkit developed for this project and a possible workflow to create different scales of cardiac tissue models from a range of CellML models. Models from the CellML repository and other sources were tested for interoperability against the MML framework. Furthermore, to demonstrate the ability of the MML framework to deploy different scales of geometry, a model of atrial electrical activation is also presented.