Title :
A generic ionic model of cardiac action potentials
Author :
Guo, Tianruo ; Abed, Amr Al ; Lovell, Nigel H. ; Dokos, Socrates
Author_Institution :
Grad. Sch. of Biomed. Eng., Univ. of New South Wales, Sydney, NSW, Australia
fDate :
Aug. 31 2010-Sept. 4 2010
Abstract :
A generic cardiac ionic model employing membrane currents based on two-gate Hodgkin-Huxley kinetics is presented. Its generic nature allows it to accurately reproduce action potential waveforms in heterogeneous cardiac tissue by optimizing parameters governing ion channel kinetics and magnitudes. The model allows a user-defined number of voltage and time-dependent ion currents to be incorporated, in order to reproduce and predict electrophysiological action potential waveforms from multiple recordings in individual cardiac myocytes.
Keywords :
bioelectric potentials; biological tissues; biomembrane transport; cardiology; medical signal processing; optimisation; physiological models; cardiac action potentials; cardiac myocytes; electrophysiological action potential waveforms; generic ionic model; heterogeneous cardiac tissue; ion channel kinetics; membrane currents; optimization; time-dependent ion currents; two-gate Hodgkin-Huxley kinetics; Biomembranes; Computational modeling; Heart; Markov processes; Mathematical model; Rabbits; Storage area networks; Action Potentials; Animals; Cells, Cultured; Computer Simulation; Heart Conduction System; Ion Channel Gating; Membrane Potentials; Models, Cardiovascular; Myocytes, Cardiac; Rabbits;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE
Conference_Location :
Buenos Aires
Print_ISBN :
978-1-4244-4123-5
DOI :
10.1109/IEMBS.2010.5626853
