Sample entropy analysis of heart rhythm following cardiac transplantation

Author

Tuzcu, Volkan ; Nas, Selman

Author_Institution

Arkansas Children´´s Hosp., Univ. of Arkansas for Med. Sci., Little Rock, AR, USA

Volume

1

fYear

2005

fDate

10-12 Oct. 2005

Firstpage

198

Abstract

Pediatric heart transplantation has become a mainstream in the treatment of end-stage heart disease in infants and children. Heart rate variability is a measure of autonomic nervous influence on the heart. After heart transplantation, the donor heart loses its nervous control. Nonlinear analysis of heart rate is a method to study the physiologic mechanisms responsible for the control of heart rate fluctuations, in which the autonomic nervous system appears to play a primary role. This work evaluated the heart rate entropy in children who has undergone heart transplantation. Patients who underwent heart transplantation showed significant decrease in entropy as assessed by sample entropy (0.63 ± 0.31 vs. 0.90 ± 0.33, p < 0.05). System complexity as can be assessed by entropy methods decreases in transplanted patients and this may be related to loss of the neural modulation of heart rate.

Keywords

electrocardiography; entropy; medical diagnostic computing; medical signal processing; paediatrics; autonomic nervous system; cardiac transplantation; heart disease; heart rate variability; heart rhythm; nervous control; neural modulation; nonlinear heart rate analysis; physiologic mechanisms; sample entropy analysis; Cardiac disease; Control system analysis; Control systems; Entropy; Fluctuations; Heart rate; Heart rate variability; Nonlinear control systems; Pediatrics; Rhythm; Transplantation; entropy; heart rate variability;

fLanguage

English

Publisher

ieee

Conference_Titel

Systems, Man and Cybernetics, 2005 IEEE International Conference on

Print_ISBN

0-7803-9298-1

Type

conf

DOI

10.1109/ICSMC.2005.1571145

Filename

1571145