Title :
Incorporating biologic tissue data into a computer model of myocardium: effects of heterogeneous sympathetic innervation on dispersion of repolarization
Author :
Wagner, Mary B. ; Dae, Michael W. ; Lesh, Michael D.
Author_Institution :
Bioeng. Graduate Group, California Univ., Berkeley, CA, USA
Abstract :
It has been suggested that heterogeneous sympathetic innervation may be involved in the development of ventricular tachycardia (VT). The authors incorporated imaging data of heterogeneous sympathetic innervation in dogs into a model a thin sheet of myocardium and showed that dispersion of repolarization (which may form part of the substrate for VT) increases with increasing heterogeneity of innervation and increasing coupling resistivity
Keywords :
bioelectric phenomena; biology computing; cardiology; digital simulation; muscle; neurophysiology; physiological models; biologic tissue data incorporation; cardiac electrophysiology; coupling resistivity; dogs; heterogeneous sympathetic innervation effects; innervation heterogeneity; myocardium computer model; repolarization dispersion; ventricular tachycardia development; Biological system modeling; Biological tissues; Biology computing; Conductivity; Dispersion; Dogs; Heart; Myocardium; Nearest neighbor searches; Nerve endings;
Conference_Titel :
Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference
Conference_Location :
Montreal, Que.
Print_ISBN :
0-7803-2475-7
DOI :
10.1109/IEMBS.1995.574984
