Lab-on-a-chip for the isolation and characterization of circulating tumor cells

Author

Stakenborg, Tim ; Liu, Chengxu ; Henry, Olivier ; O´Sullivan, Ciara K. ; Fermér, Christian ; Roeser, Tina ; Ritzi-Lehnert, Marion ; Hauch, Sigfried ; Borgen, Elin ; Laddach, Nadja ; Lagae, Liesbet

Author_Institution

Imec, SSET-FNS, Heverlee, Belgium

fYear

2010

fDate

Aug. 31 2010-Sept. 4 2010

Firstpage

292

Lastpage

294

Abstract

A smart miniaturized system is being proposed for the isolation and characterization of circulating tumor cells (CTCs) directly from blood. Different microfluidic modules have been designed for cell enrichment and -counting, multiplex mRNA amplification as well as DNA detection. With the different modules at hand, future effort will focus on the integration of the modules in a fully automated, single platform.

Keywords

DNA; bioMEMS; biomedical equipment; cellular biophysics; lab-on-a-chip; microfluidics; molecular biophysics; tumours; DNA detection; blood; cell counting; cell enrichment; lab-on-a-chip; microfluidic modules; multiplex mRNA amplification; smart miniaturized system; tumor cells; DNA; Magnetic particles; Magnetic sensors; Magnetic separation; Microfluidics; Tumors; Cell Separation; Cytophotometry; DNA, Neoplasm; Humans; Lab-On-A-Chip Devices; Neoplasms; Neoplastic Cells, Circulating; Polymerase Chain Reaction;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2010 Annual International Conference of the IEEE

Conference_Location

Buenos Aires

ISSN

1557-170X

Print_ISBN

978-1-4244-4123-5

Type

conf

DOI

10.1109/IEMBS.2010.5627655

Filename

5627655