DocumentCode :
2955532
Title :
A vertically integrated CMOS micro-system for time-resolved fluorescence analysis
Author :
Rae, Bruce R. ; Muir, Keith R. ; Renshaw, David ; Henderson, Robert K. ; Girkin, John ; Gong, Zheng ; McKendry, Jonathan ; Gu, Erdan ; Dawson, Martin D.
Author_Institution :
Joint Res. Inst. for Integrated Syst., Univ. of Edinburgh, Edinburgh, UK
fYear :
2009
fDate :
26-28 Nov. 2009
Firstpage :
85
Lastpage :
88
Abstract :
We describe a two-chip micro-scale time-resolved fluorescence analyzer integrating excitation, detection and filtering. A new 8 × 8 array of drivers integrated in standard low-voltage 0.35 ¿m CMOS is bump-bonded to AlInGaN blue micro-pixellated light-emitting diodes (micro-LED). The array is capable of producing sample excitation pulses with a width of 777 ps (FWHM) enabling short lifetime fluorophores to be excited. The fluorescence emission is detected by a second, vertically-opposed 16 × 4 array of single-photon avalanche diodes (SPADs) fabricated in 0.35 ¿m high-voltage CMOS technology with in-pixel time-gated photon counting circuitry. This constitutes the smallest reported solid-state micro-system for fluorescence decay analysis, replacing lasers, photomultiplier tubes, bulk optics and discrete electronics. The system is demonstrated with measurements of fluorescent colloidal quantum dot and Rhodamine samples.
Keywords :
CMOS integrated circuits; III-V semiconductors; aluminium compounds; avalanche photodiodes; counting circuits; fluorescence; gallium compounds; indium compounds; integrated circuit bonding; light emitting diodes; micromechanical devices; photon counting; semiconductor quantum dots; time resolved spectroscopy; wide band gap semiconductors; AlInGaN; Rhodamine samples; array; blue micropixellated light-emitting diodes; bulk optics; bump-bonding; discrete electronics; drivers; excitation pulses; filtering; fluorescence decay analysis; fluorescence emission; fluorescent colloidal quantum dot; high-voltage CMOS technology; in-pixel time-gated photon counting circuitry; photomultiplier tubes; replacing lasers; short lifetime fluorophores; single-photon avalanche diodes; size 0.35 mum; solid-state microsystem; time-resolved fluorescence analysis; two-chip microscale time-resolved fluorescence analyzer; vertically integrated CMOS microsystem; CMOS technology; Circuits; Filtering; Fluorescence; Laser excitation; Light emitting diodes; Optical arrays; Photonics; Quantum dot lasers; Space vector pulse width modulation;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Biomedical Circuits and Systems Conference, 2009. BioCAS 2009. IEEE
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-4917-0
Electronic_ISBN :
978-1-4244-4918-7
Type :
conf
DOI :
10.1109/BIOCAS.2009.5372079
Filename :
5372079
Link To Document :
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