Single-metabolite Bio-Nano-Sensors and system for remote monitoring in animal models

Author

Carrara, Sandro ; Bolomey, Léandre ; Boero, Cristina ; Cavallini, Andrea ; Meurville, Eric ; De Micheli, Giovanni ; Rezzonico, Tanja ; Proietti, Michele ; Grassi, Fabio

Author_Institution

Swiss Fed. Inst. of Technol. (EPFL), Lausanne, Switzerland

fYear

2011

fDate

28-31 Oct. 2011

Firstpage

716

Lastpage

719

Abstract

A novel system for remote monitoring of metabolism in animal model is proposed in this paper. The system is obtained by integrating Bio-Nano-Sensors to detect single-metabolites, an electrochemical front-end made with off-the-shelf components, an RF communication sub-system, and an antenna of new design. The system has been calibrated and tested for continuous monitoring of four different metabolites: glucose, lactate, glutamate, and adenosine triphosphate (ATP). Tests with animal models (mice) have been conducted to investigate tissue inflammation induced by the implanted Bio-Nano-Sensors. The tests confirmed that our system is suitable and reliable for remote monitoring of single-metabolites in experiments with animal models.

Keywords

biological tissues; biosensors; nanobiotechnology; patient monitoring; sugar; RF communication subsystem; adenosine triphosphate; animal models; glucose; glutamate; lactate; metabolism; remote monitoring; single metabolite bionanosensors; tissue inflammation; Biological system modeling; Electrodes; Mice; Monitoring; Sensors; Sugar;

fLanguage

English

Publisher

ieee

Conference_Titel

Sensors, 2011 IEEE

Conference_Location

Limerick

ISSN

1930-0395

Print_ISBN

978-1-4244-9290-9

Type

conf

DOI

10.1109/ICSENS.2011.6126962

Filename

6126962