DocumentCode :
2997076
Title :
Nano-sensor and circuit design for anti-cancer drug detection
Author :
Ghoreishizadeh, S. Sara ; Baj-Rossi, Camilla ; Carrara, Sandro ; De Micheli, Giovanni
Author_Institution :
EPFL - Ecole Polytech. Fed. de Lausanne (CH), Lausanne, Switzerland
fYear :
2011
fDate :
7-8 April 2011
Firstpage :
28
Lastpage :
33
Abstract :
The development of new technologies to monitor drugs concentration directly in patient´s blood is absolutely required to succeed in personalized drug therapies. In this study, Etoposide - a well-known anti-cancer drug - has been chosen as model for cyclic voltammetry detection of drugs. Carbon nanotubes are chosen as electron-transfer mediators to enhance the system sensitivity. A very low frequency and low slope triangular-wave potential is required to acquire cyclic voltammograms. Cyclic voltammograms are definitely needed for a correct identification and quantification of the drug concentration in the patient serum. The aim of the paper is to investigate the feasibility of VLSI fully-integration of cyclic voltammetry measurements as a tool to develop a low-cost chip for drug monitoring in personalized therapy. A triangular wave generator CMOS circuit is proposed by using Direct Digital Synthesis (DDS) method. The circuit is implemented in 0.18 μm technology and it presents the possibility of changing the slope of the triangular voltage in a wide range of 10 to 100mV/s.
Keywords :
CMOS integrated circuits; biochemistry; biomedical electronics; biosensors; blood; carbon nanotubes; drugs; nanobiotechnology; nanosensors; voltammetry (chemical analysis); Etoposide; VLSI fully-integration of cyclic voltammetry measurements; anticancer drug detection; carbon nanotubes; circuit design; cyclic voltammetry detection; direct digital synthesis method; drug concentration monitoring; electron-transfer mediators; nanosensor; patient blood serum; personalized drug therapies; triangular wave generator CMOS circuit; Biosensors; Carbon nanotubes; Current measurement; Drugs; Electric potential; Electrodes; Voltage measurement; anti-cancer drug; carbon nanotube; cyclic voltammetry; low frequency; personalized therapy; ramp-generator circuit;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Life Science Systems and Applications Workshop (LiSSA), 2011 IEEE/NIH
Conference_Location :
Bethesda, MD
Print_ISBN :
978-1-4577-0421-5
Type :
conf
DOI :
10.1109/LISSA.2011.5754147
Filename :
5754147
Link To Document :
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