32-Channel Full Customized CMOS Biosensor Chip for Extracellular Neural Signal Recording

Author

Zhang, Xin ; Daly, James C. ; Cao, Yong

Author_Institution

Dept. of Electr. & Comput. Eng., Rhode Island Univ., Kingston, RI

fYear

2005

fDate

16-19 March 2005

Firstpage

660

Lastpage

663

Abstract

In this paper we present a full-customized CMOS biosensor integrated circuit (IC) design, layout, and implementation techniques for extracellular multichannel action potential recording applications. Schematics and simulation data for each of the sub-circuit macros are presented which includes contact sensors, unity gain buffer, variable gain amplifier and logic control unit. The chip provides a satisfactory signal-to-noise ratio for neural signals with amplitudes in the range of 50-500 muV and frequency spectrum in the range of 20-2000 Hz. The prototype IC was fabricated by MOSIS using AMI´S 1.5 mum, double poly, double level metal CMOS technology

Keywords

CMOS integrated circuits; bioelectric potentials; biomedical electrodes; cellular biophysics; integrated circuit layout; microelectrodes; neurophysiology; 20 to 2000 Hz; 50 to 500 muV; MOSIS; contact sensors; double level metal CMOS technology; extracellular multichannel action potential recording; extracellular neural signal recording; full customized CMOS biosensor; integrated circuit design; integrated circuit layout; logic control unit; neural signals; unity gain buffer; variable gain amplifier; Application specific integrated circuits; Biosensors; CMOS integrated circuits; CMOS logic circuits; CMOS technology; Circuit simulation; Extracellular; Gain; Integrated circuit layout; Signal to noise ratio;

fLanguage

English

Publisher

ieee

Conference_Titel

Neural Engineering, 2005. Conference Proceedings. 2nd International IEEE EMBS Conference on

Conference_Location

Arlington, VA

Print_ISBN

0-7803-8710-4

Type

conf

DOI

10.1109/CNE.2005.1419711

Filename

1419711