DocumentCode :
3023465
Title :
Antivascular effects of pulsed low intensity ultrasound and microbubbles in mouse tumors
Author :
Goertz, David E. ; Karshafian, Raffi ; Hynynen, Kullervo
Author_Institution :
Sunnybrook Health Sci. Centre, Toronto, ON
fYear :
2008
fDate :
2-5 Nov. 2008
Firstpage :
670
Lastpage :
673
Abstract :
In this study we investigate the feasibility of inducing transient and sustained blood flow changes in murine tumors with pulsed low intensity ultrasound. Subcutaneous xenograft melanoma tumors were situated in the hind limbs of mice and exposed to 1 MHz (740 kPa) pulsed ultrasound following a bolus injection of Definitytrade microbubbles. Flow within the tumors was monitored using a 9 MHz array probe in contrast imaging mode following the bolus injection of agent during treatment, and at 2 and 24 hours post treatment. The contrast enhancement was quantified in ROIs encompassing either the periphery or center of the tumors. The results demonstrate the feasibility of producing transient reductions of flow in tumors lasting for less than 15 minutes and, with repeated exposures, the ability to induce sustained reductions in contrast enhancement in lasting for at least 24 hours. Both short and long term flow modifications have implications for the guidance and enhancement of microbubble potentiated local drug enhancement.
Keywords :
biological effects of acoustic radiation; biomedical ultrasonics; drug delivery systems; haemodynamics; tumours; Definitytrade microbubbles; antivascular effects; blood flow change; contrast enhancement; frequency 1 MHz; frequency 9 MHz; local drug enhancement; mouse tumors; pressure 740 kPa; pulsed low intensity ultrasound; subcutaneous xenograft melanoma tumors; time 2 hour; time 24 hour; Blood flow; Drugs; Malignant tumors; Medical treatment; Mice; Monitoring; Neoplasms; Optical imaging; Probes; Ultrasonic imaging; antivascular; drug; flow; microbubbles; ultrasound;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Ultrasonics Symposium, 2008. IUS 2008. IEEE
Conference_Location :
Beijing
Print_ISBN :
978-1-4244-2428-3
Electronic_ISBN :
978-1-4244-2480-1
Type :
conf
DOI :
10.1109/ULTSYM.2008.0161
Filename :
4803489
Link To Document :
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