Biosensor based on All-Polymer Resonant Microbeams

We present all-polymer resonant microbeams which can detect the adsorption of streptavidin and DNA on the surface in aqueous solution with a high selectivity. The polymer surface allows the direct functionalization with the receptor biomolecules without intermediate Au-layer. The highly sensitive resonant microbeams offer a low-cost system for disposable and label-free biosensing applications. Minimal analyte (streptavidin) concentrations of 0.025 mug/ml were detected causing an oscillation frequency shift of 1.9%. 0.13 nmol/ml of 17-mer single-stranded DNA could be selectively detected causing a frequency change of 0.9%.