Title :
Collagen micro flow channel for in vitro Blood-Brain Barrier model
Author :
Shibata, K. ; Terazono, H. ; Hattori, A. ; Yasuda, K.
Author_Institution :
Tokyo Univ., Tokyo
Abstract :
We fabricated micro flow channel based on the collagen tunnel for in vitro BBB blood capillary model using collagen gel tunnel, PDMS and infrared laser. This flow channel system can add the influence of shear stress to EC and evaluate the permeability by continuous microfluidic flow during cultivation. This system is expected to become a novel tool for emulating in vivo permeability of drug candidates available only in small quantities.
Keywords :
bioMEMS; biomechanics; blood; brain; cellular biophysics; laser applications in medicine; microchannel flow; molecular biophysics; permeability; proteins; blood capillary model; collagen gel tunnel; collagen microflow channel; collagen tunnel; continuous microfluidic flow; endothelial cell; in vitro Blood-Brain Barrier model; infrared laser; permeability; shear stress; Blood; Drugs; Etching; In vitro; In vivo; Laser modes; Microfluidics; Permeability; Power lasers; Stress;
Conference_Titel :
Microprocesses and Nanotechnology, 2007 Digest of papers
Conference_Location :
Kyoto
Print_ISBN :
978-4-9902472-4-9
DOI :
10.1109/IMNC.2007.4456328
