DocumentCode :
3062041
Title :
Stochastic probability landscape model for switching efficiency, robustness, and differential threshold for induction of genetic circuit in phage λ
Author :
Cao, Youfang ; Lu, Hsiao-Mei ; Liang, Jie
Author_Institution :
Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, 200240, China
fYear :
2008
fDate :
20-25 Aug. 2008
Firstpage :
611
Lastpage :
614
Abstract :
The genetic switch of phage lambda provides a paradigm for studying developmental biology and cell fate. Although there have been numerous experimental and theoretical studies, the mechanisms for switching efficiency, stability and robustness, maintenance of lysogenic state, and the induction lytic state are not fully understood. In this paper, a new method is adopted to account for the full stochasticity typical in small copy events and the exact steady state probability landscape of the genetic circuit of the switch network is computed. The stability and sensitivity of phage λ switch and its robustness against perturbations derived from our model for wild type and mutants are consistent with experimental data. Our study has revealed likely mechanism of the phage switch network that was previously unknown.
Keywords :
Biological system modeling; Cells (biology); Circuit stability; Genetics; Robust stability; Robustness; Steady-state; Stochastic processes; Switches; Switching circuits; Bacteriophage lambda; Computer Simulation; DNA Viruses; Gene Expression Regulation, Viral; Lysogeny; Models, Genetic; Promoter Regions, Genetic; Virus Activation;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 2008. EMBS 2008. 30th Annual International Conference of the IEEE
Conference_Location :
Vancouver, BC
ISSN :
1557-170X
Print_ISBN :
978-1-4244-1814-5
Electronic_ISBN :
1557-170X
Type :
conf
DOI :
10.1109/IEMBS.2008.4649227
Filename :
4649227
Link To Document :
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