Title :
High-throughput in vivo genetic and drug screening using femtosecond laser nano-surgery, and microfluidics
Author :
Rohde, Christopher ; Gilleland, Cody ; Samara, Chrysanthi ; Zeng, Fei ; Yanik, Mehmet Fatih
Author_Institution :
Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, USA
Abstract :
We demonstrate microfluidic devices and imaging technologies for high-speed immobilization, cellular resolution imaging, and femtosecond laser micro-surgery of awake small-animals (C. elegans) for high-throughput in vivo genetic and drug screens on neural degeneration and regeneration.
Keywords :
Animals; Drugs; Genetics; High-resolution imaging; In vivo; Isolation technology; Microfluidics; Optical imaging; Pharmaceutical technology; Ultrafast optics; Animals; Caenorhabditis elegans; Drug Evaluation, Preclinical; Microfluidic Analytical Techniques; Nanotechnology; Photons; RNA Interference; Surgical Procedures, Operative;
Conference_Titel :
Engineering in Medicine and Biology Society, 2008. EMBS 2008. 30th Annual International Conference of the IEEE
Conference_Location :
Vancouver, BC
Print_ISBN :
978-1-4244-1814-5
Electronic_ISBN :
1557-170X
DOI :
10.1109/IEMBS.2008.4649743
