Title :
Modeling cardiac ventricular cells
Author_Institution :
Dept. of Biomed. Eng., Case Western Reserve Univ., Cleveland, OH, USA
Abstract :
A mathematical model of the cardiac ventricular cell (the L-R model) is used to describe ionic currents and dynamic concentration changes during the action potential. The role of the fast and slow components of the delayed rectifier potassium current in repolarization is investigated. The model is also used to study arrhythmogenic activity of the single cell including early afterdepolarizations (EADs), delayed afterdepolarizations (DADs), and rhythmic (spontaneous and triggered activity during calcium overload). In addition, effects of various pharmacological agents on cellular behavior are simulated
Keywords :
bioelectric potentials; biomembrane transport; calcium; cardiology; physiological models; potassium; Ca; K; L-R model; action potential; arrhythmogenic activity; calcium overload; cardiac ventricular cell modeling; cellular behavior; delayed afterdepolarizations; delayed rectifier potassium current; dynamic concentration changes; early afterdepolarizations; fast components; ionic currents; mathematical model; pharmacological agents; repolarization; rhythmic activity; single cell; slow components; spontaneous activity; triggered activity; Bioelectric phenomena; Biomedical engineering; Calcium; Delay; Electric potential; Ischemic pain; Kinetic theory; Mathematical model; Protocols; Rectifiers;
Conference_Titel :
Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference
Conference_Location :
Montreal, Que.
Print_ISBN :
0-7803-2475-7
DOI :
10.1109/IEMBS.1995.574974
