Title :
A model of the adult human atrial cell
Author :
Nygren, A. ; Firek, L. ; Clark, J.W. ; Lindblad, D.S. ; Clark, R.B. ; Giles, W.R.
Author_Institution :
Dept. of Electr. & Comput. Eng., Rice Univ., Houston, TX, USA
Abstract :
We have developed a mathematical model of the electrophysiological responses in a single cell from the adult, human atrium, based on action potential and voltage clamp data recorded at 33°C. Our formulation consists of two closely interacting parts a Hodgkin-Huxley (HH) membrane equivalent circuit model for the sarcolemma, and a fluid compartment model for the intracellular medium. These simulations produce acceptable fits to experimentally recorded action potential data, and can therefore be used to gain insight into how the ionic currents interact during the action potential in human atrial cells
Keywords :
bioelectric potentials; biomembrane transport; cardiology; equivalent circuits; physiological models; 33 degC; Hodgkin-Huxley membrane equivalent circuit model; action potential; action potential data; adult human atrial cell; atrium; electrophysiological responses; fluid compartment model; intracellular medium; ionic currents; mathematical model; sarcolemma; single cell; voltage clamp data; Clamps; Equations; Equivalent circuits; Frequency dependence; Humans; Kinetic theory; Laboratories; Mathematical model; Strontium; Voltage;
Conference_Titel :
Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference
Conference_Location :
Montreal, Que.
Print_ISBN :
0-7803-2475-7
DOI :
10.1109/IEMBS.1995.574975
