Effects of ionic concentrations on propagation speed in myocardium

Author

Fieldman, A. ; Chernyak, Y.B. ; Cohen, R.J.

Author_Institution

Dept. of Phys., Harvard Univ., Cambridge, MA, USA

Volume

1

fYear

1995

fDate

20-25 Sep 1995

Firstpage

21

Abstract

The authors used their recently developed membrane model to calculate the dependence of propagation speed on shifts in the membrane´s current-voltage (I-V) relation caused by changes in the ionic environment. These shifts can be linked analytically to changes in the concentrations of cations such as Ca⁺⁺ and H⁺. The authors calculated the propagation speed using the reaction-diffusion equation for the membrane potential and obtained a value of 55 cm/s for myocardium at standard ionic concentrations. This value varied between 12 cm/s and 85 cm/s for shifts between +46 mV and -14 mV, respectively

Keywords

biodiffusion; bioelectric phenomena; biomembrane transport; cardiology; ions; muscle; physiological models; -14 mV; 46 mV; Ca; Ca⁺⁺; H; H⁺; cardiac electrophysiology; cations; ionic concentrations effects; ionic environment; membrane current-voltage relation; membrane potential; myocardium propagation speed; reaction-diffusion equation; Biomembranes; Chemical technology; Eigenvalues and eigenfunctions; Kinetic theory; Myocardium; Nonlinear equations; Physics; Polarization; Steady-state; Voltage;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference

Conference_Location

Montreal, Que.

Print_ISBN

0-7803-2475-7

Type

conf

DOI

10.1109/IEMBS.1995.574980

Filename

574980