DocumentCode :
307378
Title :
Sustained reentrant propagation in loops of decoupled cardiac cells
Author :
Papazoglou, Alexandra A. ; Barr, Roger C.
Author_Institution :
Dept. of Biomed. Eng., Duke Univ., Durham, NC, USA
Volume :
1
fYear :
1995
fDate :
20-25 Sep 1995
Firstpage :
23
Abstract :
Simulations were designed to identify the minimum number of cardiac cells that sustained propagation. Cells were connected as a loop with elevated junction resistances. The decrease in the spatial extent of the action potential associated with increasing the junction resistances to 1200 MΩ allowed propagation to be sustained in loops as small as 11 cells. Membrane kinetics spontaneously adjusted to the premature stimulation intrinsic to reentrant propagation, and thereby allowed propagation to be sustained with further decrease in the loop size. The simulations used the DiFrancesco-Noble membrane model. A minimum of 9 cells sustained propagation when the junction resistances were 1000 MΩ
Keywords :
bioelectric potentials; biomembrane transport; cardiology; physiological models; 1200 Mohm; DiFrancesco-Noble membrane model; action potential; cardiac electrophysiology; decoupled cardiac cells loops; junction resistance; loop size; membrane kinetics; premature stimulation; reentrant propagation; sustained reentrant propagation; Biomedical engineering; Biomembranes; Cardiac tissue; Conductivity; Extracellular; Immune system; Kinetic theory; Numerical models; Optical fiber cables; Thyristors;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference
Conference_Location :
Montreal, Que.
Print_ISBN :
0-7803-2475-7
Type :
conf
DOI :
10.1109/IEMBS.1995.574981
Filename :
574981
Link To Document :
بازگشت