The role of excitation contraction coupling in cardiac muscle mechanics

Author

Keurs, H. E D J Ter

Author_Institution

Dept. of Med. & Med. Physiol., Calgary Univ., Alta., Canada

Volume

1

fYear

1995

fDate

20-25 Sep 1995

Firstpage

83

Abstract

Force (F) and shortening of the myocardium during the heartbeat are determined by the amount of Ca⁺⁺ bound to Troponin-C following Ca⁺⁺ release by the sarcoplasmic reticulum (SR) which is triggered by the cardiac action potential. Troponin-C competes during this process both with other ligands in the cytoplasm of the cardiac myocyte and with the Ca⁺⁺ extrusion from the cell as well as Ca⁺⁺ re-uptake by the SR. In this discussion we address the factors that influence the main determinants of power output by the cardiac muscle

Keywords

bioelectric potentials; biomechanics; calcium; cardiology; cellular transport; muscle; Ca; Ca⁺⁺ extrusion; Ca⁺⁺ re-uptake; Ca⁺⁺ release; Troponin-C; cardiac action potential; cardiac muscle mechanics; cardiac myocyte; cell; cytoplasm; excitation contraction coupling; force; heartbeat; ligands; myocardium shortening; power output; sarcoplasmic reticulum; Bridges; Heart beat; Hospitals; Inhibitors; Laboratories; Muscles; Myocardium; Physiology; Steady-state; Strontium;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 1995., IEEE 17th Annual Conference

Conference_Location

Montreal, Que.

Print_ISBN

0-7803-2475-7

Type

conf

DOI

10.1109/IEMBS.1995.575011

Filename

575011