Characterization of DNA bio-bonds for meso-scale self-assembly

In this paper, we have investigated the use of DNA hybridization as the basis for the production of new mesoscale components. AFM experimental results are studied and compared to two theoretical approaches: molecular and thermodynamic. We explain how and why DNA hybridization process can provide a good bond to self assemble components, and how molecular modelling methods allow further understanding of the physical mechanism of this process. Furthermore, the strength interaction of DNA complementary strands is measured and analyzed using statistical tools. These results are then compared to the theoretical approaches.