Title :
Microsystem for On-Line Process Monitoring in Bioartificial Liver Support System
Author :
Xiu Xiaoqing ; Huo Xiaolin ; Li Ming ; Wu Changzhe
Author_Institution :
Inst. of Electr. Eng., Chinese Acad. of Sci., Beijing, China
Abstract :
Bioartificial liver support system based on culturing hepatocytes becomes an important research field in the treatment of acute liver failure currently. It is necessary to monitor the state of liver cell functions during the treatment of bioartificial liver support in order to guide clinical treatment. We designed a microchip-based online process monitoring system for the implementation of monitoring the activity of liver cell functions in bioreactor. The microchip was optimized by simulation analysis of fluid dynamics software. The results illustrate the effect of improvement of mixing efficiency and shortened detection time.
Keywords :
bioMEMS; bioreactors; cellular biophysics; computerised monitoring; flow simulation; liver; microfluidics; mixing; acute liver failure; bioartificial liver support system; bioreactor; fluid dynamics software simulation analysis; liver cell functions; microchip-based online process monitoring system; microsystem; mixing efficiency; Biochemical analysis; Biochemistry; Biomembranes; Bioreactors; Cells (biology); Condition monitoring; Liver; Manufacturing automation; Medical treatment; Morphology;
Conference_Titel :
Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on
Conference_Location :
Chengdu
Print_ISBN :
978-1-4244-4712-1
Electronic_ISBN :
2151-7614
DOI :
10.1109/ICBBE.2010.5515143
