Title :
Geometric Calibration Method Based Micro-CT System for Small-Animal Imaging
Author :
Hu, Zhanli ; Zou, Jing ; Gui, Jianbao ; Rong, Junyan ; Li, Yanming ; Zheng, Hairong
Author_Institution :
Paul C. Lauterbur Res. Center for Biomed. Imaging, Chinese Acad. of Sci., Shenzhen, China
Abstract :
Small-animal imaging technology has been rapidly developed for longitudinal screening of laboratory animals raised with disease developments or genetic manipulations. Micro-CT is a noninvasive imaging modality used to assess morphology and function in small-animal imaging. Geometric calibration involves the estimation of a set of parameters that describes the geometry of such systems, and is essential for accurate image reconstruction. Noo F et al (2000) have proposed a new analytic method for calibration of x-ray cone-beam scanners that use a circular path for the cone vertex. In this paper, we use this analytic calibration method for the estimation of the geometric parameters of a practical small-animal imaging micro-CT system. We improve calibration phantom of this method in order to make it more suitable for micro-CT system. The overall performance of the micro-CT system is demonstrated in some results of small-animal imaging. The projection images demonstrated that the adopt method is robust and easy to implement with high precision.
Keywords :
calibration; computerised tomography; image reconstruction; zoology; X-ray cone-beam scanner calibration; analytic method; cone vertex; disease developments; genetic manipulations; geometric calibration method; image reconstruction; laboratory animals; longitudinal screening; micro-CT system; projection images; small-animal imaging; Animals; Calibration; Diseases; Genetics; Geometry; Image reconstruction; Laboratories; Morphology; Optical imaging; X-ray imaging;
Conference_Titel :
Bioinformatics and Biomedical Engineering (iCBBE), 2010 4th International Conference on
Conference_Location :
Chengdu
Print_ISBN :
978-1-4244-4712-1
Electronic_ISBN :
2151-7614
DOI :
10.1109/ICBBE.2010.5515183