Pharmacokinetics of Metronidazole Colon-Targeted Capsules in Dogs

In order to evaluate the results of slow-release of metronidazole colon-targeted capsules, this study was undertaken to examine the pharmacokinetics of metronidazole colon-targeted capsules, normal reference tablets and colon delivery capsules in dogs. The level of metronidazole and its metabolites in serum simultaneously were measured by high performed liquid chromatography (HPLC). According to the serum drug concentration-time curves of metronidazole, pharmacokinetic parameters were calculated. The results indicated that the pharmacokinetic parameters of colon-targeted capsules were comparable to those of colon delivery capsules in dogs. But Tmax of colon-targeted capsules and normal reference tablets have significant difference. Other pharmacokinetic parameters of colon-targeted capsules and normal reference tablets were similar with each other.