Two-dimensional Axisymmetric Model for the Sensitivity Analysis of a Chronic Drug Infusion into the Brain

Author

Stiles, David K. ; Gwost, Douglas U.

Author_Institution

Medtronic Neurological, MN

fYear

2006

fDate

Aug. 30 2006-Sept. 3 2006

Firstpage

1521

Lastpage

1524

Abstract

A 64-run, 2-level partial factorial experimental analysis was conducted on a 2D axisymmetric finite-element model of the convection-enhanced drug delivery to the parenchyma of the brain. The purpose of this ANOVA analysis was to determine the relative importance of eight factors and their interaction in the volume of distribution for the drug. The analysis revealed that the infusion flowrate and concentration, the overall half-life of the drug and the in vivo effective concentration played an overwhelmingly dominant role in the drug distribution. The results of this analysis will guide the design of an appropriate drug delivery device by focusing research resources on the determined factors of most importance

Keywords

biodiffusion; brain; convection; drugs; finite element analysis; neurophysiology; physiological models; sensitivity analysis; statistical analysis; ANOVA analysis; brain; chronic drug infusion flow rate; convection-enhanced drug delivery; drug distribution; finite-element model; in vivo effective concentration; parenchyma; partial factorial experimental analysis; sensitivity analysis; two-dimensional axisymmetric model; Alzheimer´s disease; Analysis of variance; Brain modeling; Catheters; Drug delivery; Extracellular; Finite element methods; Parkinson´s disease; Region 1; Sensitivity analysis;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society, 2006. EMBS '06. 28th Annual International Conference of the IEEE

Conference_Location

New York, NY

ISSN

1557-170X

Print_ISBN

1-4244-0032-5

Electronic_ISBN

1557-170X

Type

conf

DOI

10.1109/IEMBS.2006.260548

Filename

4462053